Neoadjuvant therapy for resectable pancreatic cancer
نویسندگان
چکیده
منابع مشابه
Neoadjuvant therapy for resectable pancreatic cancer
The use of neoadjuvant therapies has played a major role for borderline resectable and locally advanced pancreatic cancers (PCs). For this group of patients, preoperative chemotherapy or chemoradiation has increased the likelihood of surgery with negative resection margins and overall survival. On the other hand, for patients with resectable PC, the main rationale for neoadjuvant therapy is tha...
متن کاملNeoadjuvant Therapy for Resectable and Borderline Resectable Pancreatic Cancer
The majority of patients with localized pancreatic cancer (PC) who undergo surgery followed by adjuvant therapy will develop metastatic disease, suggesting that surgery alone is not sufficient for cure and micrometastases are present even when are not clinically detected. As such, the delivery of early systemic therapy may be a rational alternative to a surgery-first approach, in an effort to p...
متن کاملNeoadjuvant therapy in resectable pancreatic cancer: a critical review.
BACKGROUND Pancreatic cancer is among the deadliest tumors. Due to intrinsic chemo- and radio-resistance, surgical resection remains the only chance for cure. However surgery alone is unable to considerably improve survival and complementary chemotherapy and radiotherapy in a multimodal approach have been tested. Adjuvant chemotherapy yielded a modest outcome improvement, whereas the use of adj...
متن کاملNeoadjuvant therapy in pancreatic cancer
The overall survival for carcinoma pancreas is still around 5%. Surgical resection alone is associated with a low survival and high recurrence rates. Neoadjuvant therapy for carcinoma pancreas is aimed at improving survival and resectability by downsizing borderline resectable and unresectable tumors. However its role in the resectable group of patients is still not clear. This review discussed...
متن کاملUpdates on the use of neoadjuvant therapy in borderline resectable pancreatic cancer.
Pancreatic cancer is an aggressive and devastating cancer that continues to have high 5-year mortality rates despite advancements in the field. Surgery remains the only curative treatment; however, most patients present with late stage disease deemed unresectable. By refining the resection guidelines to include a borderline resectable group, as well as advancements in neoadjuvant chemotherapy a...
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ژورنال
عنوان ژورنال: World Journal of Gastrointestinal Oncology
سال: 2017
ISSN: 1948-5204
DOI: 10.4251/wjgo.v9.i12.457